High Q Technologies and structural biology contract research organization Creative Biostructure have formed a strategic partnership to expand research access to electron paramagnetic resonance (EPR) spectroscopy systems. The collaboration integrates High Q Technologies’ FATHOM® EPR platform with Creative Biostructure’s experimental design and analytical workflows. The joint framework is structured to assist pharmaceutical and biotechnology organizations in incorporating quantum-enabled molecular sensing into active drug discovery pipelines, simplifying the hardware and operational complexities that have historically restricted the use of EPR techniques.
Technical Architecture & Quantum Resonance Performance
The FATHOM® platform addresses the measurement limitations of conventional structural biology tools when analyzing disordered, flexible, or highly dynamic protein complexes. While established methods like cryo-electron microscopy (cryo-EM) and X-ray crystallography resolve high-resolution static atomic coordinates, they struggle to capture the transient conformational ensembles and folding intermediates that drive disease pathology. EPR spectroscopy resolves this by mapping the long-range distances and magnetic interactions between unpaired electrons attached to specific spin labels on a biomolecule.
To enhance sensitivity and reduce the sample volume requirements that typically stall commercial biological evaluations, High Q Technologies replaces traditional microwave cavity detectors with a cryogenic quantum sensor core. This quantum-enabled sensor layout delivers high-precision magnetic field resolution, detecting subtle Zeeman split-level energy changes in microgram-scale protein concentrations. The resulting spectroscopic data maps molecular motion and distance variables in real time, providing a hardware-validated dataset to benchmark targeted therapeutics against intrinsically disordered proteins and protein aggregation pathways.
Workflow Integration & Cross-Methodology Validation
The commercialization roadmap pairs this quantum sensing hardware with Creative Biostructure’s structural analysis services to lower the technical barrier to entry for non-specialist research teams. Led by Managing Director Don Carkner at High Q Technologies and Principal Scientist Tony Zhang at Creative Biostructure, the partnership sets up a consultation and data-interpretation loop. This framework blends EPR data streams directly with classical structural biology techniques, using the long-range distance metrics from the FATHOM® platform to constrain and refine three-dimensional molecular models generated via nuclear magnetic resonance (NMR) spectroscopy and machine-learning-driven structural predictions.
The official joint partnership release can be found via the Business Wire newsroom here. For technical service specifications, assay options, and custom experimental design protocols, access the primary Creative Biostructure services portal here.
June 3, 2026
Leave A Comment